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NFL Matchups: Predictions, Odds & Betting Trends

Sun, 9/28, Final: 26 – 21
Jacksonville Jaguars @ San Francisco 49ers

Jaguars: 2-1 (66.7%) - AFC South | Market Rating: -0.04

49ers: 3-0 (100.0%) - NFC West | Market Rating: +0.48 | Home Field: +1.5 pts

Line: -3.5

Total: 45.5

Open: -3.5

Open: 45.5

Team totals: Jaguars 20.5 · 49ers 24.5