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NFL Matchups: Predictions, Odds & Betting Trends

Sun, 12/1, Final: 10 – 35
San Francisco 49ers @ Buffalo Bills

49ers: 5-6 (45.5%) - NFC West

Bills: 9-2 (81.8%) - AFC East

Line: -6.5

Total: 45.5

Open: -3.5

Open: 47.5

Team totals: 49ers 19.5 · Bills 26.5