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Updated: 11/10/26 1:58 p.m. ET
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NFL Matchups: Predictions, Odds & Betting Trends

Sun, 9/22, Final: 20 – 13
Detroit Lions @ Arizona Cardinals
Lions: 1-1 (50.0%) - NFC North
Cardinals: 1-1 (50.0%) - NFC West
Line: +3.0
Total: 51.5
Open: +4
Open: 51.5
Team totals: Lions 27.5 · Cardinals 24.5